Assistant Professor of Computer Science
Assistant Professor of Biochemisty
Joined department: Spring 2017
Dr. Kazemian research interests span the areas of computational biology and immunology to studying gene regulation in viral associated cancers (e.g. EBV and HBV caused tumors), autoimmune disorders (e.g. Rheumatoid Arthritis), and infectious diseases (e.g. COVID-19). His lab utilizes biological assays (single-cell and bulk high-throughput sequencing data) and computational models to identify novel biological pathways, new host-pathogen interactions and regulatory RNAs (e.g. enhancer RNAs and circular RNAs) that could trigger disease.
B. Yan, T. Freiwald, D. Chauss, L. Wang, E. West, J. Bibby, M. Olson, S. Kordasti, D. Portilla, A. Laurence, M. Lionakis, C. Kemper, B. Afzali, M. Kazemian, SARS-CoV2 drives JAK1/2-dependent local complement hyper-activation, https://doi.org/10.1126/sciimmunol.abg0833, Science Immunology, (2021).
A. Osman, B. Yan, Y. Li, K. Pavelko, J. Quandt, A. Saadalla, M. Rathore, M. Kazemian, F. Gounari, K. Khazaie, TCF1 controls Treg functions that regulate inflammation, CD8 T-cell cytotoxicity, and severity of colon cancer, pre-print, doi:10.21203/rs.3.rs-136816/v1, Nature Immunology, In press, (2021).
B. Yan, S. Chakravorty, C. Mirabelli, L. Wang, J. Trujillo-Ochoa, D. Chauss, D. Kumar, M. Lionakis, M. Olson, C. Wobus, B. Afzali, M. Kazemian, Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual, https://doi.org/10.1128/JVI.00294-21, Journal of Virology (2021).
Chakravorty, B. Yan, C. Wang, J. Majumder, L. Wang, J. Quaid, C. Lin, S. D. Briggs, M. Olson, A. Canaria, D. Chauss, G. Chopra, B. Afzali, B. Zhao, M. Kazemian, Integrated pan-cancer map of EBV-associated neoplasms reveals functional host-virus interactions, Cancer Research, (2019).
J. Martinez-Fabregas, L. Wang, E. Pohler, A. Cozzani, M. Kazemian, S. Mitra, I. Moraga, CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci, Cell Reports, doi: 10.1016/j.celrep.2020.108545, (2020).