Title: At the Limits of Computation: How Nature Deals with the Physical Constraints on Computation William B Levy, Ph.D. Professor of Neurosurgery & of Psychology University of Virginia Charlottesville, VA Abstract: This talk will address, from a biological perspective, constraints on computation including time, energy, and space (size). Because evolution has had a long time to work out computation and communication within the brain, there is reason to suspect that it is microscopically optimized. It is certainly true that, at the micron and submicron level, certain basic principles and parameterizations (e.g., the voltages, capacitance, the signal shape) are found throughout the animal kingdom. Sometimes the optimizations make sense - short distance communication is analog, long distance communication is binary, and sometimes they may be surprising. E.g., more energy is spent on communication than on computation, but little energy used for communication goes to improving signal-to-noise ratio. From the computational perspective there are, perhaps, other counterintuitive constructions. E.g., a special kind of randomness actually improves computation and the energy efficiency of computation. The required neuroscience is minimal and will be defined in the lecture.