Selected Projects:
- Annotation Patterns in
Biological Networks : Recent efforts have been successful in
producing large amounts of interaction data, as well as annotations of
bio-molecules involved in them. We develop tools to integrate these
datasets to reveal modular and overrepresented patterns that
underlie cellular organization.
- Functional Coherence :
Bio-molecules like proteins are associated with multiple functional
annotations, which may be noisy, incomplete or generic. We develop
similarity measures in a formal setting for such data, and use it to
investigate relationship of functional coherence and topological
proximity.
- Synteny and Function : It is known that gene order is not
random in prokaryotic and eukaryotic genomes, and that rearrangements
occur frequently. We study how synteny (preservation of gene order)
affects gene regulation, expression and function.
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Contact Info:
3133, Lawson Computer Science Building,
305 N. University Street,
Purdue University,
West Lafayette, Indiana, 47907-2066
Ph: (765) 496 9405
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